Figure 1
Figure 1. Wladyslaw Antoni Gluzinski around 1930. In 1906, Professor A. Gluzinski and Dr M. Reichenstein described the first case of pPCL in the “Wiener Klinische Wochenschrift.”3,7 At that time, the authors worked in the University Hospital of Lemberg (Lvov), which was then part of the Austrian Empire, but is now one of the main cities in western Ukraine. Professor Gluzinski was born in Wloclawek (Poland) in 1856 and died in Warsaw in 1935.100 The authors describe a 47-year-old train ticket inspector who presented with bone pain, a palpable mass over one of his ribs, rib fractures, anemia, and splenomegaly. Urine contained large amounts of a proteinaceous substance. In the blood smear, the authors observed erythroblasts and immature plasma cells, sometimes with 2 or 3 nuclei. The absolute number of circulating tumor cells increased significantly during further follow-up (one week before patient died, leucocytes were estimated at 39.4 × 109/L, containing 91% plasma cells). The diagnosis of MM and “leucaemia lymphatica plasmocellularis” was made. Treatment consisted of the organoarsenic compounds Atoxyl and Neoarsicodile. This was followed by a brief period with reduced levels of pain and reduction of the size of the rib tumor, enabling him to resume working. However, the pain and rib tumors recurred and the patient died 6 months after his first presentation of pneumonia. Autopsy confirmed the premortem diagnosis. Interestingly, much later, several groups reported activity from arsenic in MM and related disorders.

Wladyslaw Antoni Gluzinski around 1930. In 1906, Professor A. Gluzinski and Dr M. Reichenstein described the first case of pPCL in the “Wiener Klinische Wochenschrift.”3,7  At that time, the authors worked in the University Hospital of Lemberg (Lvov), which was then part of the Austrian Empire, but is now one of the main cities in western Ukraine. Professor Gluzinski was born in Wloclawek (Poland) in 1856 and died in Warsaw in 1935.100  The authors describe a 47-year-old train ticket inspector who presented with bone pain, a palpable mass over one of his ribs, rib fractures, anemia, and splenomegaly. Urine contained large amounts of a proteinaceous substance. In the blood smear, the authors observed erythroblasts and immature plasma cells, sometimes with 2 or 3 nuclei. The absolute number of circulating tumor cells increased significantly during further follow-up (one week before patient died, leucocytes were estimated at 39.4 × 109/L, containing 91% plasma cells). The diagnosis of MM and “leucaemia lymphatica plasmocellularis” was made. Treatment consisted of the organoarsenic compounds Atoxyl and Neoarsicodile. This was followed by a brief period with reduced levels of pain and reduction of the size of the rib tumor, enabling him to resume working. However, the pain and rib tumors recurred and the patient died 6 months after his first presentation of pneumonia. Autopsy confirmed the premortem diagnosis. Interestingly, much later, several groups reported activity from arsenic in MM and related disorders.

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