Figure 5
![Control of established GVHD by DZNep. (A) Diagram shows the experimental design. Lethally irradiated BALB/C recipients (8 Gy [800 rad]) were transplanted with B6 mice–derived TCD BM (5 × 106; n = 8) or with TCD BM + CD4+ TN cells (1 × 106). CD4+ T-cell recipients were treated with 12 doses of DZNep (n = 20) or vehicle (■; n = 10) from day 7 to day 29 after transplantation. (B) Tissues were collected on day 7 and day 60 after transplantation for histologic examination. Graphs (mean ± SD) show the histologic score of GVHD. (C) The survival and clinical signs were monitored over time.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/119/5/10.1182_blood-2011-06-364422/4/zh89991184740005.jpeg?Expires=1720844766&Signature=WvjK09iBWRP9SuNuGImRXvTsOFXLRcews6ONgu4NdHADVK4rq6o69A~1ogg7BGnmnZMnUXpR0hkIGYrZHHBP9ziFzoyDZ574WkA5QMx8RPWHDdm8v6S-MOHuWcyQyzzg9NLoFmXuzviYjf5QnfK21h3Kf-FSTIV~Ubon3Iyi01SVCJzdrQ08oIBi4kcVhD0i46h7AGIuw9j3unFBRLdrFmTlg0Dm73gX-9iS8g85sgWweJVrd6Fm-SIS-PJkJYFyD5KhKf8JzPhIBMKUfacqh2lRYOEHVOnFF7rZQfaMhMdHFYtS2KPHxaDBLoKdiAgti1E-UGRc~YEKmWvUrhEl4Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Control of established GVHD by DZNep. (A) Diagram shows the experimental design. Lethally irradiated BALB/C recipients (8 Gy [800 rad]) were transplanted with B6 mice–derived TCD BM (5 × 106; n = 8) or with TCD BM + CD4+ TN cells (1 × 106). CD4+ T-cell recipients were treated with 12 doses of DZNep (n = 20) or vehicle (■; n = 10) from day 7 to day 29 after transplantation. (B) Tissues were collected on day 7 and day 60 after transplantation for histologic examination. Graphs (mean ± SD) show the histologic score of GVHD. (C) The survival and clinical signs were monitored over time.
