Figure 4
Figure 4. Pediatric-type FL (cohort 1) with unusual morphologic features. Some FL cases lacking BCL2 rearrangement and with HPI were composed of small follicles (A) containing predominantly small centrocytes and few centroblasts (B). The Ki67 proliferation index is high (C), and the CD20+cells (D) lack expression of BCL2 protein (E). Higher-power image of BCL2 (F) and CD3 (G) staining of same field shows no expression of BCL2. Panels A, D, and E were captured at ×40 magnification; F and G at ×100 magnification; B at ×1000, and C at ×400 magnification with the use of an Olympus, BX53 microscope, Olympus DP25 digital camera.

Pediatric-type FL (cohort 1) with unusual morphologic features. Some FL cases lacking BCL2 rearrangement and with HPI were composed of small follicles (A) containing predominantly small centrocytes and few centroblasts (B). The Ki67 proliferation index is high (C), and the CD20+cells (D) lack expression of BCL2 protein (E). Higher-power image of BCL2 (F) and CD3 (G) staining of same field shows no expression of BCL2. Panels A, D, and E were captured at ×40 magnification; F and G at ×100 magnification; B at ×1000, and C at ×400 magnification with the use of an Olympus, BX53 microscope, Olympus DP25 digital camera.

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