Differing impact of HIT treatment and prevention strategies. The timeline of HIT begins with intra-/perioperative “point immunization” followed 1 week later by thrombocytopenia and hypercoagulability. Whereas “late” HIT-associated thrombosis can be prevented by an effective alternative anticoagulant, only a HIT prevention strategy can avoid morbidity from early HIT-associated thrombosis. Disruption of immunizing PF4/heparin complexes by intra-/perioperative coadministration of ODSH with heparin could prevent HIT and, consequently, HIT-associated thrombosis.