Figure 7
Emergence of NK-cell progenitors and NK cells in the mouse embryo. Schematic representation of where and when NK-cell progenitors and different NK-cell populations arise during fetal development. iNK indicates immature NK cells (CD3−NK1.1+DX5+), mNK, mature NK cells (CD3−NK1.1+DX5+CD43+Mac-1+), and tNK, thymic NK cells (CD3−CD25−CD122+NK1.1+Ly49D−IL-7R+). Cytotoxic NK cells were identified as CD107a+ using the degranulation assay.

Emergence of NK-cell progenitors and NK cells in the mouse embryo. Schematic representation of where and when NK-cell progenitors and different NK-cell populations arise during fetal development. iNK indicates immature NK cells (CD3NK1.1+DX5+), mNK, mature NK cells (CD3NK1.1+DX5+CD43+Mac-1+), and tNK, thymic NK cells (CD3CD25CD122+NK1.1+Ly49DIL-7R+). Cytotoxic NK cells were identified as CD107a+ using the degranulation assay.

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