Performance of the 7-gene (9-probe set) SPCA model of EFS in MLL-AFF1 cases. Kaplan-Meier survival curves showing prediction of EFS and relapse-free survival in our cohort and the independent validation cohort. (A) The 7-gene model separates the 47 MLL-AFF1 cases into low- and high-risk groups with significantly different EFS. (B) Validation cohort of 22 MLL-AFF1 cases are similarly separated into 2 groups with significantly different EFS based on our model. (C) The 7 gene model also significantly separates the 36 older (> 90 days) MLL-AFF1 infants into low- and high-risk groups. (D) Model overlaps significantly with the P9407 MLL-AFF1 unsupervised clusters; however, it also adds significant predictive risk information, particularly in the HOXA pattern cases.