Typing of systemic amyloidosis through MS-based diagnostic algorithm in 26 patients. Bars in the graph represent the α-values of the 4 amyloid proteins in each patient. α-value is the normalized patient over control ratio of each amyloid protein's spectral count (see supplemental Methods). Amyloidosis is attributed to the type whose corresponding amyloid protein has the highest α-value. Discontinuous line indicates the theoretical diagnostic threshold (α-value = 70; see supplemental Methods). Based on this algorithm, all patients were correctly classified (ie, amyloid-type definition was in accordance with IEM).