Clinical manifestations in a family with WHIM syndrome. (A) Pedigree consistent with autosomal-dominant inheritance. (B) Representative area of skin warts on patient P1. Arrows point to clusters of representative warts on the dorsum of the right hand. (C) BM biopsy from P1 showing full myeloid maturation in the face of peripheral neutropenia, which is consistent with myelokathexis (400×). Arrows point to representative mature neutrophils and granulocyte precursors and an eyeglass-shaped neutrophil in which pyknotic nuclear lobes were connected by a long filament.