TF isoforms exert cellular effects via PAR2 and integrin ligation. The membrane-bound flTF/FVIIa complex signals via the G-coupled PAR2^{4,24,25,30,31,43}  when coupled to α6β1 or α3β1 integrins.^28-30  The phosphorylation status of the flTF cytoplasmic domain balances protease activated receptor (PAR2) signaling.^27,29,31  asTF ligates α6β1 and αVβ3 integrins, leading to signaling via focal adhesion kinases (FAK), independent of FVIIa and PAR2.⁵  The resulting signaling pathways regulate cell survival and motility and induce release of angiogenic factors.^4,5,23-25,30  PI3 indicates phosphatidylinositol-3′; MAP, mitogen-activated protein; CXCL-1, chemokine ligand-1; and VEGF, vascular endothelial growth factor.