Scatter plot showing the phenotypic variables on the x-axis, with each dot being an event-positive representative at its corresponding age level. The y-axis represents age at diagnosis in years. The variables are not exclusive because a case with an IgH break might also be displayed in as being IgH-BCL2 translocation positive. Note that this visualization is distorted by the skewed distribution of age at diagnosis. The color code indicates membership of each variable to an individual group: green represents gene expression; red, chromosomal translocation/breaks; blue, chromosomal copy number gains; orange, chromosomal copy number losses; magenta, immunohistochemistry markers; gray, morphology; and black, EZH2 Tyr 641 mutation status. The span from 24 to 36 years in which visual inspection reveals a strong increase in several molecular features is highlighted in gray.