Identification of binding site and computational screening. (A) The PF4 antagonist binding pocket (black circle) is located on the surface of the PF4 dimer (red and blue ribbons) near residues Lys50 (yellow) and Glu28 (green). (B) Distribution of DOCK scores for potential PF4 antagonists; 109 compounds have scores more than 10 SD below the mean (red box).