Kaplan-Meier curves for onset of CMC and outcome. (A) Onset of CMC. Exact age at onset of CMC was available for 253 patients. (B) Overall survival curves. Age at the time of the study was available for 269 patients. Patients with severe complications (ie, patients who displayed invasive infections, aneurysms, and/or tumors) were compared with patients without any severe complication (log-rank test, P < .001).