Figure 7
Figure 7. Deletion of cd36 rescues accelerated thrombus formation induced by AGE injection in vivo. (A) AGE-BSA or BSA was injected directly into wt or cd36-null mice through the jugular vein and allowed to circulate for 20 minutes. Plasma levels of AGEs were then assessed by ELISA. Graph shows means ± SEM. (B) Mice treated as in panel A were subjected to FeCl3-induced thrombosis as in Figure 3. Representative images of intracarotid thrombi at the indicated time points are shown (top) and the bar graph shows the mean times to occlusive thrombosis (n > 6 for all groups).

Deletion of cd36 rescues accelerated thrombus formation induced by AGE injection in vivo. (A) AGE-BSA or BSA was injected directly into wt or cd36-null mice through the jugular vein and allowed to circulate for 20 minutes. Plasma levels of AGEs were then assessed by ELISA. Graph shows means ± SEM. (B) Mice treated as in panel A were subjected to FeCl3-induced thrombosis as in Figure 3. Representative images of intracarotid thrombi at the indicated time points are shown (top) and the bar graph shows the mean times to occlusive thrombosis (n > 6 for all groups).

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