DM accelerates arterial thrombus formation in mice in vivo in a CD36-dependent manner. (A) Age-matched wt or cd36-null mice were maintained on chow, DBD, or WD for 8 weeks and then subjected to FeCl₃-induced carotid artery injury to induce thrombus formation. STZ indicates chow-fed mice treated with STZ to induce pancreatic islet destruction and type 1 DM. Platelets were labeled in vivo by injection of rhodamine 6G and thrombi were imaged by fluorescence videomicroscopy. Representative images obtained at various time points are shown. (B) Time to occlusive thrombus formation was assessed using 6-8 mice per group.