Risk classification of patients with AML. Risk classification scheme based on features at diagnosis and the presence of MRD. LR indicates low-risk; HR, high-risk; and AR, allelic ratio. Patients with t(8;21), inv(16), or t(16;16) are considered to be provisional LR regardless of other genetic alterations. Patients with NPM1 mutations or biallelic CEBPA mutations are provisional LR, except in the presence of FLT3-ITD. Provisional LR patients are moved to the intermediate-risk group if they are MRD-positive after one course of induction therapy. HR patients include those with any of the features indicated in the box on the lower left, regardless of response to therapy. Patients who lack LR and HR features are provisionally classified as intermediate risk but are moved to the HR group if they have a poor response to therapy as assessed by MRD.