Figure 7
![Figure 7. 01A selectively blocks APRIL-induced protection in MM cells, alone and in cocultures with OCs, an effect that is further enhanced by lenalidomide or bortezomib. (A) U266 cells were incubated with APRIL or IL-6 in the presence or absence of lenalidomide, with or without 01A (10 μg/mL), and assayed by [3H]thymidine uptake at day 3. MM cell lines were cultured for 4 days in 2% fetal calf serum growth media with OCs in the presence of 01A with either (B) lenalidomide or (C) bortezomib. *P < .01.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/25/10.1182_blood-2016-01-691162/4/3225f7.jpeg?Expires=1725417810&Signature=tR4BRusD2C5p9pyrqN5TFzdrL3kOFzwCNgFv7w7NX7wQPVTW6c~u3WL7dvkX~xZBxH-LeRK-gPMbOcgEpwgk7zp2-DklotqjE8kNSHH5PILKhwd6Cn69LVwJsXvdrSBIdff01neXLrtGCutqG8XkSTx3nQy-zdfnE8IAGhjlFN4ukGWN51FRf~rIHp0ohAec8RST-w3MyiiE-Ti1hbqsA9~pWNp3r8tNwXp3RzrddRsW~pyDadRlomWadXcLfo3WZL8CH3JBs8XuaCMd7b6gOuYzaeWBV4~wS5d1qjXAo0Y~ikmt8st2jty1QgcgCbMkWxuCPq8ChRk0yKjN9QtJ6g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
01A selectively blocks APRIL-induced protection in MM cells, alone and in cocultures with OCs, an effect that is further enhanced by lenalidomide or bortezomib. (A) U266 cells were incubated with APRIL or IL-6 in the presence or absence of lenalidomide, with or without 01A (10 μg/mL), and assayed by [3H]thymidine uptake at day 3. MM cell lines were cultured for 4 days in 2% fetal calf serum growth media with OCs in the presence of 01A with either (B) lenalidomide or (C) bortezomib. *P < .01.
