Tail-clip assay in hemophilia A mice after BM transplantation. (A) Cumulative survival after tail-clip in control untreated mice and mice after transplantation of 2 × 106 or 10 × 106 BM cells. Animals were studied between 8 weeks to 52 weeks after BM transplantation. Total animal numbers are given at bottom and number of surviving mice with percentage survival is at top of bars. Only the difference in survival between untreated controls versus animals in the 2 treatment groups was significant (P < .0001; Fisher exact test). (B) Plasma FVIII activity in mice surviving was greater than mice not surviving after tail-clip assay in both groups (P < .001; t test). Mouse plasma FVIII activity of 100% represented 1.02 IU/mL of human FVIII standard.
