Kinetics of thrombocytopenia development in ADAMTS13 KO mice at early time points after rhVWF challenge. Animals were administered 2000 VWF:RCoU/kg BW of rhVWF (●), and platelet counts were determined at the time points (4 animals each) indicated up to 9 hours. Compared with untreated control animals (time point 0), platelet counts were already reduced by approximately 33% after 5 minutes and by 95% after 9 hours.