Prognostic value of immune profiling using second-generation MFC. (A) Two-dimensional PCA plot of the patients’ immune profiles defined by the distribution of 13 immune cell populations (excluding normal and clonal PCs) in the BM at the time of MRD assessment (n = 146). (B-C) The distribution of the 13 immune cell populations in clusters A (n = 16), B (n = 116), and C (n = 13) is shown in panel B, whereas in panel C shows TTP and OS according to the patients’ immune-profile clusters. NK, natural killer; NKT, natural killer T cells.