Figure 3
![Figure 3. Mx-Cre deletion of Spry1 worsens, and prolongs, hemolysis-induced anemia. (A) Conditional Spry1−/− and wild-type control mice were challenged by hemolysis (phenylhydrazine [PHZ]; 70 mg/kg). At the indicated intervals, red cell mass was assayed (hematocrits). Values are mean ± SE (n = 4). (B) Analyses of erythroid cells in spleen at day 3.5 after phenylhydrazine revealed an approximate 270% elevation in frequencies of Spry1-deficient stage E1 progenitors.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/119/23/10.1182_blood-2011-11-392571/4/zh89991291700003.jpeg?Expires=1722776357&Signature=YQTOTajViNRdybx8HM4eIKQK4-InjZUrYOBQH6P-Ro2jVZaSbEPddNZvTKkPwpimXkpOQeLBZFRVS9OGQ7UrFAxu-FWxNSNNt-bWR8ckBfoEc7AO0MeDw5U0Ve-Ma7gH4WrbTmAeuwm8TIfBtZ38W1jNNBqZq7qlJzfjm3Y6lVkWHTC8cUIjtYVXyQjpSJJmSBCA8ae39bj6J-c9224D15x60Yzl6BU0juotCELOLrWX-M3MpaepNY8friD3L0xsKd9Ou8yS0Fv9f6n-xe6KBoR0QgPc4QcCQxjjZpoTh~Cx8oFX6LacPpsx4-z6k~inCAOweyf1EkVNE2gw-zo5Qg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Mx-Cre deletion of Spry1 worsens, and prolongs, hemolysis-induced anemia. (A) Conditional Spry1−/− and wild-type control mice were challenged by hemolysis (phenylhydrazine [PHZ]; 70 mg/kg). At the indicated intervals, red cell mass was assayed (hematocrits). Values are mean ± SE (n = 4). (B) Analyses of erythroid cells in spleen at day 3.5 after phenylhydrazine revealed an approximate 270% elevation in frequencies of Spry1-deficient stage E1 progenitors.
