TFs and chromatin-modification enzymes targeted by HoxB4 and differentially expressed. (A) TFs. (B) Chromatin-modification enzymes. Differential gene expression between 2 adjacent time points was detected using the Limma algorithm¹⁶  with an FDR cutoff of 0.005. Each column in the dendrogram represents a comparison of data from 2 adjacent time points. For example, D0/D6 represents comparison between day 0 and day 6 data. Each cell represents combined gene-expression and HoxB4-binding information for a given gene; green, up-regulated and targeted by HoxB4; red, down-regulated and targeted by HoxB4; black, not targeted by HoxB4.