Kaplan-Meier analyses of treatment outcomes. (A) Time-to-study discontinuation among the 4 treatment arms, irrespective of the reason for discontinuation (mITT population). The median time to discontinuation was nearly 6 months for all treatment groups with the most common reason being a decision to proceed to stem cell transplantation. (B) PFS from randomization, irrespective of whether the patient proceeded to stem cell transplantation (mITT population). (C) PFS from randomization, with patients proceeding to stem cell transplantation censored at the time of transplantation (mITT population). (D) Overall survival from randomization in the 4 treatment groups (mITT population).