CLL Ig repertoire: one-third stereotyped, two-thirds heterogeneous. A continuous increase in cohort size results in a nonproportional increase in the frequency of VH CDR3 stereotypy. This is best depicted when considering the fact that despite a significant increase in sample size between the present series and the largest published series (almost 5000 additional cases), the increase in the frequency of stereotypy was only 2.4% (data are shown using a logarithmic trendline).