Stereotypes in CLL are disease-biased. As an example, the cross-entity comparison of VH CDR3 sequences among rearrangements from CLL and MCL using the same IGHV genes showed clear differences in a series of molecular features: IGHD and IGHJ gene utilization and also VH CDR3 length and amino acid composition. The height of symbols within the stack indicates the relative frequency of each amino or nucleic acid at that position. Amino acid position is according to the IMGT numbering for V domain.²⁷