Cebpa-Cre–mediated Dicer1 deletion affects gene expression in GMPs. (A) Cumulative distribution plot of the log fold change of transcripts that contain miRNA-binding sites for the identified miRNAs (supplemental Table 2) and messages that do not contain sites compared with wild-type (P < 2.2 × 10⁻¹⁶). (B) Cumulative distribution plot of log fold change for mRNA containing miRNA-binding sites for the identified miRNAs (supplemental Table 2) in the indicated populations. The expression ratio of most messages in Dicer1^Δ/Δ cells over Dicer1^wt/Δ and Dicer1^wt are skewed toward higher positive fold changes compared with Dicer1^wt/Δ over Dicer1^wt (P < 2.2 × 10⁻¹⁶). (C) Significant differentially expressed genes between GMP wild-type and Dicer1^Δ/Δ cells (FDR-corrected P < .05) were unsupervised clustered with GPLOTS (http://cran.r-project.org/web/packages/gplots/index.html).