Frequency of cytogenetic alterations and of additional molecular mutations in MLD⁺ and MLD⁻ patients. Red indicates a positive characteristic of the respective marker and gray indicates negativity. White cells show that the evaluation was not done for this patient. In the case of MRC,¹⁶  red shows the adverse-risk group and gray shows intermediate risk. Patients are depicted vertically. In cases of CEBPA subtype, dark red shows biallelic, medium red shows monoallelic, and bright red shows homozygous CEBPA mutations.