Endoscopic and histologic features of a representative gastric pure (de novo) DLBCL responsive to HPE therapy. Before treatment, multiple irregular-shaped ulcers with residual nodular mucosa at the entire gastric body (A) and diffuse large cells infiltrate in the lamina propria in histology (B-C; H&E, ×400 and ×1000, respectively). Six weeks after HP eradication, complete regression of all diffuse ulcerations with hyperemic and atrophic mucosa at the entire gastric body (D) and biopsy showed prominent eosinophils with scatter small lymphoid cells infiltrate in the lamina propria (E-F). Neither large cells nor features of MALT lymphoma were seen (H&E, ×400 and ×1000, respectively). Six months after HP eradication, nearly normal-appearing mucosa with some wide-based whitish scar at the body of the stomach (G) and biopsy shows scatter small lymphocytes infiltrate only the lamina propria (H-I; H&E, ×100 and ×400, respectively). All slides were observed with light microscopy. An Olympus BX60 microscope equipped with 10×/0.40, 40×/0.95, and 100×/1.35 objective lenses (Olympus) was used to visualize images. Pictures were taken with an Olympus DP70 camera, and Adobe Photoshop 6.0 was used to enlarge the images to their present magnification levels (Adobe Systems).