Bioinformatic analysis reveals that AML1/ETO and AML1 bind to adjacent and specified motifs on chromatin. (A) Examples of the AML1/ETO and AML1 overlap peaks. Vertical blue lines indicate the peak summits of AML1/ETO; vertical red lines indicate the peak summits of AML1. (B) The distance between the summit of AML1/ETO and AML1 binding on the overlap peaks. (C) Significant motifs identified within the AML1/ETO and AML1 overlap regions. (D) Percentages of the AML1/ETO and AML1 overlapped regions that contain the short and/or long AML1 motifs. (E) Frequency distribution of the short and long AML1 motifs relative to the AML1/ETO and AML1 peak summits on the overlap regions containing both motifs.