Effect of Tmprss6 haploinsufficiency on hematologic parameters of thalassemic mice. Time course analysis of RBC count, Hb levels and MCV of male and female WT, Tmprss6^+/−, Hbb^th3/+ (th3/+) and Tmprss6^+/−Hbb^th3/+ (Tmprss6^+/−th3/+) mice. Mean values of 4 to 8 animals for sex and genotype are graphed and error bars indicate SD. Asterisks refer to a statistically significant difference between Hbb^th3/+ and Tmprss6^+/−Hbb^th3/+ mice (*P < .05; **P < .01; ***P < .005). For complete statistical analysis see supplemental Table 3.