Degranulation capacity and IFN-γ production by target-stimulated NK cells before cART initiation. Total degranulation (total CD107a⁺ expression [A]), degranulation without IFN-γ production (CD107a⁺IFN-γ⁻ [B]), and total IFN-γ production (IFN-γ⁺ [C]) are compared across the different groups. For HIV-infected patients, the results are those obtained before cART. Results are medians (75th-25th percentiles). Outside values are indicated by points. Significant P values are indicated.