Proteomic profiles of #M3 patient cells (in blue). #M3 patient cells share some characteristics of ZAP70⁻ M-CLL cells, such as HCLS1 and LSP1 profiles, but also some features of aggressive responders ZAP70⁺ UM-CLL cells, such as decrease of RAD23B and PDCD4 after anti-IgM activation. Points corresponded to expression levels of HCLS1, LSP1, PDCD4, or RAD23 proteins in US or S M-CLL, Mr-CLL (#M3 patient), and UM-CLL cells.