Figure 4
Figure 4. Cited2 deficiency results in decreased HSC reconstitution capacity. (A) WBC count in PB was monitored 0, 4, 8, 12, and 16 days after 5-FU treatment in WT and Cited2Δ/Δ mice (n = 8). (B) Survival time was monitored for at least 18 days. Overall survival time in Cited2Δ/Δ mice was significantly shorter than controls (n = 8). (C) Absolute numbers of donor-derived B cells (B220+), myeloid cells (Mac-1+ or Gr-1+), and T cells (CD3+) in PB 16 weeks after noncompetitive transplantation (means ± SEM, n = 6). (D) PB chimerism in recipients at 16 weeks after competitive transplantation (means ± SEM, n = 4).

Cited2 deficiency results in decreased HSC reconstitution capacity. (A) WBC count in PB was monitored 0, 4, 8, 12, and 16 days after 5-FU treatment in WT and Cited2Δ/Δ mice (n = 8). (B) Survival time was monitored for at least 18 days. Overall survival time in Cited2Δ/Δ mice was significantly shorter than controls (n = 8). (C) Absolute numbers of donor-derived B cells (B220+), myeloid cells (Mac-1+ or Gr-1+), and T cells (CD3+) in PB 16 weeks after noncompetitive transplantation (means ± SEM, n = 6). (D) PB chimerism in recipients at 16 weeks after competitive transplantation (means ± SEM, n = 4).

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