Clinical response to T-cell infusions. Patient UPN-04 was treated with CY 1 g/m2 2 days before the first of 3 infusions of αCD20-28-BB-ζ CAR+ T cells, which were given 2 to 5 days apart and followed by 14 days of subcutaneous IL-2 injections. (A) Response in a cervical lymph node as imaged by CT scan of the neck at baseline and 1, 6, and 12 months after T-cell infusions. (B) PET-CT scan of the cervical lymph node at baseline and 3 months after T-cell infusions. (C) Change in tumor volume over time. The sum of the products of the diameters of the 7 largest lymph nodes seen on the baseline and 1-, 6-, and 12-month CT scans. (D) Heterogeneity of response in individual lymph nodes. The products of the diameters of the 7 largest lymph nodes from the 6-month CT scan are shown as a percentage of their baseline size. L indicates left; and R, right.
