SC-EPOCH-RR treatment paradigm. Patients receive 2 cycles of SC-EPOCH-RR and are then restaged by CT and FDG-PET scanning. Patients in CR after 2 cycles receive one more cycle (minimum 3) of therapy. Patients with a “positive” CT and/or FDG-PET study after 2 cycles receive additional cycles until they were negative, for a maximum of 6 cycles.