Assessment of relative risk for bleeding following ISIS 416858 or enoxaparin treatment. Cynomologus monkeys were administered PBS, ISIS 416858 (20 mg/kg/wk) or enoxaparin (2 mg/kg) for up to 6 weeks by SC injection. Following anesthesia, animals were subject to (A) a partial tail amputation or (B) gum or skin laceration, and blood volume and/or bleeding time were recorded. Data represents mean ± SD. *Statistical difference from the control group (P < .05).