Dexamethasone and lenalidomide induce distinct but overlapping gene-expression profiles. The heat map (panel A) illustrates the top 25 genes induced by dexamethasone (Dex), lenalidomide (Len), and the combination of both drugs. Genes induced by one drug and the combination are labeled as genes induced by the combination. The genes were arranged by hierarchical clustering. High gene expression is portrayed in red and low expression is blue. Expression of RPS19 and RPS14 in response to drug treatment is shown in panels B and C, respectively.