Figure 2
Figure 2. CD160 expression in normal lymphocytes is restricted to NK and T cells. (A) CD160 expression on normal donor HSCs gated on the CD34+CD117+ cells (n = 5). (B) CD160 expression on immature reactive benign B-cell precursors, termed hematogones, that are typically CD19+CD10+CD34+CD38+ (n = 5). (C) CD160 expression on pre-B cells from BM samples that lack surface immunoglobulin but are CD19+CD10+CD34− (n = 6). (D) CD19+CD38+IgD− GC cells from both tonsils and lymph nodes (n = 6). (E) UCB showing CD160 and CD19 expression on CD5+ cells (n = 5). (F) Normal peripheral blood NK cells demonstrating CD160 positivity (n = 30). (G) Normal peripheral blood mononuclear B cells (n = 30). (H) Normal B1 cells from a healthy donor (n = 30). (I) CD45−/dimCD38+CD138+ terminally differentiated plasma cells from BM samples (n = 5). (J) Percentage CD160 expressed on individual cell types. PB indicates peripheral blood; LNBx, lymph node biopsy. Secondary lymphoid organs are splenic and tonsillar material.

CD160 expression in normal lymphocytes is restricted to NK and T cells. (A) CD160 expression on normal donor HSCs gated on the CD34+CD117+ cells (n = 5). (B) CD160 expression on immature reactive benign B-cell precursors, termed hematogones, that are typically CD19+CD10+CD34+CD38+ (n = 5). (C) CD160 expression on pre-B cells from BM samples that lack surface immunoglobulin but are CD19+CD10+CD34 (n = 6). (D) CD19+CD38+IgD GC cells from both tonsils and lymph nodes (n = 6). (E) UCB showing CD160 and CD19 expression on CD5+ cells (n = 5). (F) Normal peripheral blood NK cells demonstrating CD160 positivity (n = 30). (G) Normal peripheral blood mononuclear B cells (n = 30). (H) Normal B1 cells from a healthy donor (n = 30). (I) CD45−/dimCD38+CD138+ terminally differentiated plasma cells from BM samples (n = 5). (J) Percentage CD160 expressed on individual cell types. PB indicates peripheral blood; LNBx, lymph node biopsy. Secondary lymphoid organs are splenic and tonsillar material.

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