fXIII-Treatment of wild-type mice and bacterial dissemination. Mice received a subcutaneous injection of S pyogenes and were treated with FibrogamminP 3 hours after infection. Nontreated mice served as controls. Twenty-four hours after infection, mice were killed and bacterial loads in the blood (A), liver (B), and spleen (C) were determined. Data are presented as means of 10 mice per group and were obtained from 3 independent experiments. *P < .05; **P < .01.