Spectrum of lymphoproliferations in mice with homozygous deletion of the CDR, MDR, and miR-15a/16-1. The fraction of CLL among the various types of B-lymphoproliferations in mice with homozygous deletion of the CDR, MDR, and miR-15a/16-1 was statistically evaluated among the respective cohorts. CDR−/− group: CDRfl/−CD19-Cre and CDRfl/flCD19-Cre mice; MDR−/− group: MDR−/− and MDRfl/−CD19-Cre mice22 ; miR-15a/16-1−/− group: miR-15a/16-1−/− and miR-15a/16-1fl/−CD19- Cre mice.22