Mice with heterozygous deletion of the CDR develop lymphoproliferations and show an indolent disease course. (A) Percentages of CD5⁺B220^lo cells among mononuclear cells of mice from the CDR^+/− cohort. P values are indicated. For further details, see the legend to Figure 2. (B) Percentages of B-lymphoid pathologies observed in 15- to 18-month-old mice of the CDR^+/− cohort. For further details, see the legend to Figure 4. (C) Percentage of event-free survival in the CDR^+/− cohort. Mice were followed for 20 months. Events comprised illness or mice identified as moribund or sick (palpable tumor or visible ascites), which were killed. P values between the CDR^+/− and wild-type mice are indicated. The number of mice of each genotype is indicated in brackets. Mice shown in panels B and C correspond to different cohorts.