ADAMTS13 deficiency accelerates atherosclerosis in the aortic sinus. (A) Representative photomicrographs of VerHoeffs/Van Geison-stained aortic sinuses from female mice on a high-fat Western diet beginning at 6 weeks until they were killed at 4 months of age (ie, 10 weeks on high-fat Western diet). Bar represents 200μm. (B) Quantification of lesion in the cross-sectional area of aortic sinuses from female mice (N = 10-13/group). (C) Representative photomicrographs of VerHoeffs/Van Geison–stained aortic sinuses from male mice on a high-fat Western diet as described for female. Bar represents 200 μm. (D) Quantification of lesion in the cross-sectional area of aortic sinuses from male mice (N = 9 or 10/group). Each dot represents a single mouse. Horizontal bars represent mean values.