Acute and chronic GVHD and overall survival after transplantation of BM and PBPCs. (A) The day 100 cumulative incidence of grades 2 to 4 acute GVHD after PBPC and BM transplantation. Grades 2 to 4 acute GVHD risks were higher after transplantation of PBPCs compared with BM (HR = 1.68; 95% CI, 1.10-2.55, P = .02) and transplantation of either graft in male recipients from female donors (HR = 2.33; 95% CI, 1.45-3.57, P = .0004). (B) The 3-year cumulative incidence of chronic GVHD after PBPC and BM transplantation in patients younger than 20 years and 20 years or older at transplantation. After adjusting for age at transplantation, chronic GVHD risks were not different after transplantation of PBPC and BM (HR = 1.39; 95% CI, 0.90-2.16, P = .14). Risks were higher in patients older than 20 years (HR = 1.97; 95% CI, 1.29-3.01, P = .002). (C) The 3-year probabilities of overall survival after PBPC and BM transplantation, adjusted for performance score and transplant conditioning regimen. Overall mortality risks were higher after transplantation of PBPCs compared with BM (HR = 1.62; 95% CI, 1.01-2.58, P = .04), in patients with performance score less than or equal to 80 (HR = 1.93; 95% CI, 1.20-3.10, P = .01), and those who received non-TBI conditioning regimens (HR = 1.68; 95% CI, 1.08-2.62, P = .02). Mortality risks were higher in patients older than 20 years, although this did not reach statistical significance (HR = 1.61; 95% CI, 0.98-2.63, P = .06).