Notch blockade results in defective lymphangiogenesis during wound healing. (A) Wound gap size in control (PBS), αDll4, and αVEGF-A treated mice for 12 days after punch biopsy (n = 5; *αDll4 treatment, P < .05; **αVEGF-A treatment, P < .05). (B) Images of CD31 (green) and LYVE1 (red) costaining of the skin dermis in PBS- (control), αDll4-, or αVEGF-A–treated mice 12 days after a full thickness cutaneous wound. Dotted line represents the approximate skin/wound margin and arrow represents the edge of wound closure. Scale bar represents 500 μm.