Position and types of GATA1 sequence mutations found in TMD and ML-DS samples. (A) A schematic diagram of GATA1 showing the positions and types of the sequence mutations found in TMD and ML-DS samples. Each arrow represents a different patient. (B) Diagram showing the mutational spectrum of patients with TMD and with ML-DS and (C) the effect that these mutations have on the sequence of GATA1.