Figure 2
Platelet inhibitors reduce thrombin generation in histone-treated PRP. Recalcified CTI-inhibited PRP was treated with 10 μmol/L of PGE1 or 50 μmol/L of cilostazol (A), 10 U/mL of apyrase or 1 μmol/L of cangrelor (B), or 1.5 μmol/L of tirofiban (C) for 10 minutes at 37°C before stimulation with histones (40 μg/mL). Thrombin generation was then evaluated by CAT. A representative experiment of 4 performed with PRP from different donors is shown.
