Tumorigenesis in c-fms-rtTA/(tetO)7-CMV-dnPPARγ–bitransgenic mice. (A) H&E and immunohistochemical staining of lung tissue sections with anti–SP-C Ab in the tumor areas of doxycycline-treated bitransgenic mice. Untreated mice served as controls. (B) H&E and immunohistochemical staining of liver tissue sections with anti-Mac2, F4/80, B220, CD3, Ki67, and lysozyme Abs in the tumor areas of doxycycline-treated bitransgenic mice. Untreated mice served as controls. Original magnifications were 40×, 200×, and 400×. (C) H&E and immunohistochemical staining of spleen tissue sections with anti-Ki67, B220, CD3, F4/80, and lysozyme Abs in the tumor areas of doxycycline-treated bitransgenic mice. Untreated mice served as controls. Original magnifications were ×100 and ×200. (D) H&E and immunohistochemical staining of lymph node tissue sections with anti-Mac2, B220, CD3, and Ki67 Abs in the tumor areas of doxycycline-treated bitransgenic mice. Untreated mice served as controls. Original magnifications were ×200 and ×400.
