Changes in plasma levels of selected cytokines and inflammatory markers in patients included in phase 2 of the study. Plasma levels of 46 cytokines and inflammatory proteins were evaluated in samples obtained at baseline and after 1 month of therapy. The HumanMAP Version 1.6 panel (Rules-Based Medicine), was used for this analysis. Results are shown as heat map, with each row indicating the plasma marker and the columns corresponding to individual patients. In the left part of the plot, corresponding to baseline samples, the green and red denote proteins that were present in the patients at lower or higher levels, respectively, relative to normal control subjects. In the columns on the right, corresponding to 1 month of treatment, red and green indicate the proteins whose levels increased or decreased, respectively, compared with the baseline level for the same patient.