PFS: all patients, by treatment. Cox model for treatment, stratified random effects (frailty) model for study: HR = 0.68 (95% CI, 0.61-0.76); P < .0001. Median survival: MP 14.9 months (95% CI, 14.0-16.6 months); MPT 20.3 months (95% CI, 18.8-21.5 months).