OS: all patients, by treatment. Cox model for treatment, with analysis stratified by study using a random effects (frailty) model: HR = 0.83 (95% CI, 0.73-0.94) in favor of MPT; P = .004. Median survival: MP 32.7 months (95% CI, 30.5-36.6 months); MPT 39.3 months (95% CI, 35.6-44.6 months).