Dynamic representation of clonal dominance in the presence of TET2 and/or JAK2 mutations in the HSC, hematopoietic stem progenitor (HPC), and mature fractions. JAK2V617F would mainly expand the mature fraction, whereas TET2 mutation would mainly expand the HPC fraction. TET2 and JAK2 mutations are synergistic by combining an early and late amplification. The order of mutations would not matter if they occur before the development of a full-blown disorder. All numbers and ratios are arbitrary.